Traumatic brain injury and the pathways to cerebral tau accumulation

Tau is a protein that has received national mainstream recognition for its potential negative impact to the brain. This review succinctly provides information on structure of tau and normal physiological functions, including in hibernation changes throughout estrus cycle. There are many pathways involved phosphorylating diabetes, stroke, Alzheimer’s disease (AD), brain injury, aging, drug use. The common mechanisms these processes put into context with observed mild repetitive traumatic injury (TBI). phosphorylation part progression pathology, but ability aggregate propagate also addressed. Summarizing both functional dysfunctional roles can help advance our understanding this complex protein, improve care individuals history TBI, lead development therapeutic interventions prevent or reverse tau-mediated neurodegeneration.